Comprehensive Analysis of Human Endogenous Retrovirus Transcriptional Activity in Human Tissues with a Retrovirus-Specific Microarray
نویسندگان
چکیده
منابع مشابه
Human endogenous retrovirus-like sequences.
One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed "provirus", can then serve as a template for the synthesis of further infectious virus particles. Stably integrated proviruses have been found to...
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Recent studies suggest that autism spectrum disorders (ASD) result from interactions between genetic and environmental factors, whose possible links could be represented by epigenetic mechanisms. Here, we investigated the transcriptional activity of three human endogenous retrovirus (HERV) families, in peripheral blood mononuclear cells (PBMCs) from Albanian ASD children, by quantitative real-t...
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The etiology of viruses in osteoarthritis remains controversial because the prevalence of viral nucleic acid sequences in peripheral blood or synovial fluid from osteoarthritis patients and that in healthy control subjects are similar. Until now the presence of virus has not been analyzed in cartilage. We screened cartilage and chondrocytes from advanced and non-/early osteoarthritis patients f...
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BACKGROUND It has been suggested that Human endogenous retroviruses (HERVs) are associated with multiple sclerosis (MS) pathogenesis. The objective of this study was to broadly evaluate the expression of HERV core (GAG) and envelope (ENV) genes in diseased brain white matter samples from MS patients compared to normal controls. METHODS Twenty-eight HERV GAG and 88 ENV gene sequences were retr...
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The human genome represents a fossil record of ancient retroviruses that once replicated in the ancestors of contemporary humans. Indeed, approximately 8% of human DNA is composed of sequences that are recognizably retroviral. Despite occasional reports associating human endogenous retrovirus (HERV) expression with human disease, almost all HERV genomes contain obviously inactivating mutations,...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2005
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.79.1.341-352.2005